Herpes simplex Virus 2 Antigen BA1052VS

Additional Information:
targetHerpes simplex Virus 2|species reactivityHerpes Simplex Virus|applicationsELISA|assay typeIndirect & quantitative|available size1 mg|Herpes simplex Virus 2 Antigen BA1052VSkitResearch areaInfectious DiseaseStorageStore at -65C or lower. Avoid repeated freeze-thaw cycles. Sonicate before use. 10 years from date of manufacture (under recommended storage conditions).FormliquidAssociated productsHerpes simplex Virus 2 Glycoprotein G Antigen (BA1052RVS-G)Herpes simplex Virus 2 Antigen (BA1052VS)Herpes Simplex Virus 2 gP IgG Control Serum (BC1052G)Herpes Simples Virus 2 IgM Control Serum (BC1052M)Herpes simplex Virus 2 IgG ELISA Kit (ESR1052G)Herpes simplex Virus 2 IgM ELISA Kit (ESR1052M)target relevanceOrganismHerpes Simplex Virus 1/2Structure and strainsHerpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomic names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Both HSV-1 and HSV-2 are very common and contagious. They can be spread when an infected person begins shedding the virus. As of 2016, about 67% of the world population under the age of 50 had HSV-1. In the United States, about 47.8% and 11.9% are estimated to have HSV-1 and HSV-2, respectively, though actual prevalence may be much higher. Because it can be transmitted through any intimate contact, it is one of the most common sexually transmitted infections.DiseaseHerpes Simplex Virus 1 (HSV 1) and Herpes Simplex Virus 2 (HSV 2) are DNA viruses belonging to the family of Herpesviridae. They occur globally. In industrialized countries the seroprevalence amounts to 50% in the second decade of life, in adults even up to 90% for HSV 1 and 10 to 15% for HSV 2. The transmission of Herpes Simplex Virus 1 occurs by contact with contaminated salivary or smear infection. Herpes Simplex Virus 2 is transmitted via contact with infected mucosal skin. Primary HSV 1 infections process inapparently in 90% of cases. 10% of infected persons suffer from inflammations of cornea and conjunctiva or show the characteristic herpes vesiculation at the lips. These pustular eruptions can spread on eczematous skin with life-threatening effects. Other complications are encephalitis or meningoencephalitis. 12% of primary HSV 2 infections are apparent with sudden abortion, vulvovaginitis or penis scrotum efflorescences.Detection and diagnosisAn important field of application for HSV serology – also during latency – is the detection of serotype-specific HSV IgG antibodies in order to identify potential HSV carriers who could infect susceptible individuals. In particular, the identification of HSV 2 serotype-specific antibodies in pregnant women, who present a high risk of transferring the virus to a newborn child, is recommended. The serological typing of an HSV infection is usually performed by identifying IgG antibodies directed against the viral surface glycoproteins G (gG) of HSV 1 (gG1) and HSV 2 (gG2). Due to the fact that these antibodies are only produced some weeks after a primary infection, the determination of serotype-specific antibodies can also assist in the differentiation between primary infection and reactivation|