Product Name :
TC-G 1004
Description:
TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively.
CAS:
1061747-72-5
Molecular Weight:
421.50
Formula:
C22H27N7O2
Chemical Name:
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxypiperidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Smiles :
CC1C=C(C)N(N=1)C1N=C(C=C(NC(C)=O)N=1)C1=CC=CC(=N1)N1CCC(CC1)OC
InChiKey:
JENSDTKXNVHSSN-UHFFFAOYSA-N
InChi :
InChI=1S/C22H27N7O2/c1-14-12-15(2)29(27-14)22-25-19(13-20(26-22)23-16(3)30)18-6-5-7-21(24-18)28-10-8-17(31-4)9-11-28/h5-7,12-13,17H,8-11H2,1-4H3,(H,23,25,26,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively.|Product information|CAS Number: 1061747-72-5|Molecular Weight: 421.50|Formula: C22H27N7O2|Chemical Name: N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxypiperidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide|Smiles: CC1C=C(C)N(N=1)C1N=C(C=C(NC(C)=O)N=1)C1=CC=CC(=N1)N1CCC(CC1)OC|InChiKey: JENSDTKXNVHSSN-UHFFFAOYSA-N|InChi: InChI=1S/C22H27N7O2/c1-14-12-15(2)29(27-14)22-25-19(13-20(26-22)23-16(3)30)18-6-5-7-21(24-18)28-10-8-17(31-4)9-11-28/h5-7,12-13,17H,8-11H2,1-4H3,(H,23,25,26,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.CTEP Autophagy |Shelf Life: ≥12 months if stored properly.Romosozumab manufacturer |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:34763923 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TC-G 1004 (compound 16j) is a highly potent A2A antagonist at both the human and rat receptors with greater than 100× selectivity over hA1.|In Vivo:|TC-G 1004 (compound 16j, 3 mg/kg) displays good in vivo oral activity in rat models for Parkinson’s disease and were advanced to preclinical development. TC-G 1004 (compound 16j) dose-dependently potentiates L-dopa induced rotations with an MED of 3 mg/kg when dosed orally.|Products are for research use only. Not for human use.|
