Non-small cell lung cancer (NSCLC) continues to pose significant therapeutic challenges, especially in patients without actionable EGFR mutations. While first-generation EGFR tyrosine kinase inhibitors (TKIs) like erlotinib have shown remarkable…
The detection and characterization of post-translational modifications (PTMs) in intact proteins remain a central challenge in proteomics. This study presents a high-resolution mass spectrometry approach using capillary zone electrophoresis (CZE)…
Helicobacter pylori gamma-glutamyl transpeptidase (GGT) is a critical virulence factor that plays a central role in the pathogenesis of H. pylori infection. This enzyme catalyzes the hydrolysis of glutamine into…
A 30-year-old Japanese man with no prior psychiatric history presented to our clinic in May 2011 with persistent delusions lasting two months. He reported an intense belief that someone was…
Paraquat (PQ) poisoning remains a life-threatening condition with high mortality due to the absence of an effective antidote. The primary mechanism of PQ toxicity involves the generation of reactive oxygen…
V2a interneurons in the ventral spinal cord and hindbrain are critical components of central pattern generators (CPGs) governing locomotion, skilled reaching, and respiration. Despite their functional importance, reliable in vitro…
Plasma membrane NADPH oxidases (Noxs) are key producers of reactive oxygen species (ROS) in plants under both normal physiological conditions and various environmental stresses. In this study, we identified at…
Postoperative nausea and vomiting (PONV) remain a common and distressing complication following middle ear surgery, particularly tympanoplasty and mastoidectomy. With an incidence as high as 80% in the absence of…
Prostatic acid phosphatase (PAP), also known as ACPP, has long served as a biomarker for prostate cancer. Recent studies have revealed that both secretory and transmembrane isoforms of PAP exhibit…
**Background** Bacterial infections caused by Gram-positive, Gram-negative, and anaerobic organisms remain a significant challenge in clinical medicine, requiring potent antimicrobial agents that can target essential bacterial enzymes. Beyond its antimicrobial…