Product Name :
AZD-8529 mesylate
Description:
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
CAS:
1314217-69-0
Molecular Weight:
583.58
Formula:
C25H28F3N5O6S
Chemical Name:
7-methyl-5-{3-[(piperazin-1-yl)methyl]-1,2,4-oxadiazol-5-yl}-2-{[4-(trifluoromethoxy)phenyl]methyl}-2,3-dihydro-1H-isoindol-1-one; methanesulfonic acid
Smiles :
CC1C=C(C=C2CN(CC3C=CC(=CC=3)OC(F)(F)F)C(=O)C=12)C1=NC(CN2CCNCC2)=NO1.{{Karanjin} MedChemExpress|{Karanjin} Cytochrome P450|{Karanjin} Technical Information|{Karanjin} Formula|{Karanjin} custom synthesis|{Karanjin} Epigenetic Reader Domain} CS(O)(=O)=O
InChiKey:
HRHCPVNKPOTCGB-UHFFFAOYSA-N
InChi :
InChI=1S/C24H24F3N5O3.CH4O3S/c1-15-10-17(22-29-20(30-35-22)14-31-8-6-28-7-9-31)11-18-13-32(23(33)21(15)18)12-16-2-4-19(5-3-16)34-24(25,26)27;1-5(2,3)4/h2-5,10-11,28H,6-9,12-14H2,1H3;1H3,(H,2,3,4)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.|Product information|CAS Number: 1314217-69-0|Molecular Weight: 583.58|Formula: C25H28F3N5O6S|Chemical Name: 7-methyl-5-{3-[(piperazin-1-yl)methyl]-1,2,4-oxadiazol-5-yl}-2-{[4-(trifluoromethoxy)phenyl]methyl}-2,3-dihydro-1H-isoindol-1-one; methanesulfonic acid|Smiles: CC1C=C(C=C2CN(CC3C=CC(=CC=3)OC(F)(F)F)C(=O)C=12)C1=NC(CN2CCNCC2)=NO1.CS(O)(=O)=O|InChiKey: HRHCPVNKPOTCGB-UHFFFAOYSA-N|InChi: InChI=1S/C24H24F3N5O3.CH4O3S/c1-15-10-17(22-29-20(30-35-22)14-31-8-6-28-7-9-31)11-18-13-32(23(33)21(15)18)12-16-2-4-19(5-3-16)34-24(25,26)27;1-5(2,3)4/h2-5,10-11,28H,6-9,12-14H2,1H3;1H3,(H,2,3,4)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 41.{{Tegoprubart} site|{Tegoprubart} Technical Information|{Tegoprubart} Data Sheet|{Tegoprubart} supplier|{Tegoprubart} Epigenetic Reader Domain} 67 mg/mL (71.40 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23558135 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC50 of 195 nM . AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM.|In Vivo:|AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats.|Products are for research use only. Not for human use.|
